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Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5

Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li

Frontiers of Medicine 2019, Volume 13, Issue 6, Pages 705-712 doi: 10.1007/s11684-019-0703-y

Abstract: Wnt and Notch signaling play crucial roles in the determination of the prosensory domain and in the differentiation of hair cells (HCs) and supporting cells during mouse inner ear development; however, the relationship between the two signaling pathways in the mouse cochlea remains largely unknown. Here, we investigated the interactions between Notch and Wnt signaling on the basis of the bidirectional regulation of Notch1 specifically in Wnt-responsive Lgr5 progenitors during different cochlear development stages. We found that the downregulation of Notch1 in Lgr5 cells from embryonic day (E) 14.5 to E18.5 can drive the quiescent Lgr5 cells to re-enter the cell cycle and differentiate into extra HCs, whereas the upregulation of Notch1 expression did not affect the proliferation or differentiation of otic progenitor cells. No effect was observed on the upregulation or downregulation of Notch1 in Lgr5 cells from E10.5 to E14.5. We concluded that the roles of Notch1 in Wnt-responsive Lgr5 cells are unidirectional and stage dependent and Notch1 serves as a negative regulator for Lgr5 progenitor activation during cochlear differentiation. Our findings improved the understanding of the interactions between Notch and Wnt signaling in cochlear development.

Keywords： inner ear cochlear Wnt Notch Lgr5 auditory system

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P50 auditory sensory gating in first onset schizophrenics and normal healthy adults

WANG Hongxing, ZHANG Mingdao, CHEN Xingshi, LOU Feiying, LIANG Jianhua, CHEN Chong, SHI Tiantao, LU Qiulin

Frontiers of Medicine 2007, Volume 1, Issue 4, Pages 429-432 doi: 10.1007/s11684-007-0084-5

Abstract: The aim of this research was to investigate the variations of P50 auditory sensory gating (P50) in normalBy using the American Nicolet Bravo electromyography/evoked potential (EMG/EP) system, P50 was measured

Keywords： anterior Positive S2-P50 schizophrenic EMG/EP

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Behavioral methods for the functional assessment of hair cells in zebrafish

Qin Yang, Peng Sun, Shi Chen, Hongzhe Li, Fangyi Chen

Frontiers of Medicine 2017, Volume 11, Issue 2, Pages 178-190 doi: 10.1007/s11684-017-0507-x

Abstract:

Zebrafish is an emerging animal model for studies on auditory system.Zebrafish displays a series of innate and robust behavior related to its auditory function.Here, we reviewed the advantage of using zebrafish in auditory research and then introduced three behavioral

Keywords： zebrafish (Danio rerio) behavior auditory startle response vestibular-ocular reflex rheotaxis

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Past review, current progress, and challenges ahead on the cocktail party problem Review

Yan-min QIAN, Chao WENG, Xuan-kai CHANG, Shuai WANG, Dong YU

Frontiers of Information Technology & Electronic Engineering 2018, Volume 19, Issue 1, Pages 40-63 doi: 10.1631/FITEE.1700814

Abstract: cocktail party environment, and describe the conventional single-channel techniques such as computational auditory

Keywords： Cocktail party problem Computational auditory scene analysis Non-negative matrix factorization Permutation

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Towards human-like and transhuman perception in AI 2.0: a review Review

Yong-hong TIAN,Xi-lin CHEN,Hong-kai XIONG,Hong-liang LI,Li-rong DAI,Jing CHEN,Jun-liang XING,Jing CHEN,Xi-hong WU,Wei-min HU,Yu HU,Tie-jun HUANG,Wen GAO

Frontiers of Information Technology & Electronic Engineering 2017, Volume 18, Issue 1, Pages 58-67 doi: 10.1631/FITEE.1601804

Abstract: Perception is the interaction interface between an intelligent system and the real world.review the state-of-the-art advances across different areas of perception, including visual perception, auditoryperception for the forthcoming era of AI 2.0, including: (1) human-like and transhuman active vision; (2) auditoryperception and computation in an actual auditory setting; (3) speech perception and computation in a

Keywords： Intelligent perception Active vision Auditory perception Speech perception Autonomous learning

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System reliability and system resilience

Frontiers of Engineering Management 2021, Volume 8, Issue 4, Pages 615-619 doi: 10.1007/s42524-021-0176-y

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Engineering, Engineering System, Engineering System Theory, and System of Engineering Science

Wang Liancheng

Strategic Study of CAE 2001, Volume 3, Issue 6, Pages 15-18

Abstract: of basic contents, nature and feature of engineering, this paper introduces concepts of engineering systemand engineering system theory, then discusses objects of study and research methods of engineering systemtheory using thinking of general system theory.Finally, it expounds meta-discipline standing of engineering system theory in system of engineering science

Keywords： engineering system system theory discipline

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Cyber–Physical Power System (CPPS): A review on measures and optimization methods of system resilience

Frontiers of Engineering Management 2021, Volume 8, Issue 4, Pages 503-518 doi: 10.1007/s42524-021-0163-3

Abstract: The Cyber–Physical Power System (CPPS) is one of the most critical infrastructure systems in a country

Keywords： Cyber–Physical Power System resilience assessment resilience optimization cascading failure modeling

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Discussion on the System Optimization of the Energy Development Strategy and Plan

Da-di Zhou

Frontiers of Engineering Management 2014, Volume 1, Issue 2, Pages 147-152 doi: 10.15302/J-FEM-2014022

Abstract: Due to the complexity of the energy system, the interactive relationship with economic and social development, and the enormous investment involved, the optimization of the energy system is of great significanceefforts to develop targets and specific approaches for the rational and optimal development of an energy system

Keywords： energy development strategy planning system system optimization

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Distributed monitoring and diagnosis system for hydraulic system of construction machinery

Xiaohu CHEN, Wenfeng WU, Hangong WANG, Yongtao ZHOU,

Frontiers of Mechanical Engineering 2010, Volume 5, Issue 1, Pages 106-110 doi: 10.1007/s11465-009-0089-7

Abstract: This paper mainly presents a distributed monitoring and diagnosis system for the hydraulic system ofThe hardware of the distributed condition monitoring and fault diagnosis system is designed.experiments and applications indicate that the distributed condition monitoring and fault diagnosis systemrealize its function of real-time online condition monitoring and fault diagnosis for the hydraulic system

Keywords： construction machinery hydraulic system distributed condition monitoring controller area net (CAN) field

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Theory and method of mechanism system design

Huijun ZOU, Qinghua LIANG, Qing ZHANG

Frontiers of Mechanical Engineering 2010, Volume 5, Issue 4, Pages 399-411 doi: 10.1007/s11465-010-0116-8

Abstract: Conceptual design is the most critical and creative phase of design. Recently, increasing attention has been directed to supporting conceptual-level computer aided creative design and its theories and methodologies. Specifically, for conceptual design of mechanical products, this paper presents a novel function solving model for mechanical product design and highlights the importance of systematic synthesis to achieve creative design. Then it builds a framework as a function-effect-process-action- mechanisms (FEPAM) mapping process, which enables creative design on the basis of conceiving different action schemes. After that, several key points are elaborated including 1) representing and decomposition methods of functions and motion behaviors; 2) action scheme representing method based on network plan techniques; and 3) variation and creation methods based on action scheme transformations.

Keywords： mechanism system creative design process model function solving model process action procedure mechanismsknowledge base principle of mechanism system composition

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Dynamic contribution of variable-speed wind energy conversion system in system frequency regulation

Yajvender Pal VERMA, Ashwani KUMAR

Frontiers in Energy 2012, Volume 6, Issue 2, Pages 184-192 doi: 10.1007/s11708-012-0185-y

Abstract: from the grid during disturbances with advanced power electronics controllers and reduce equivalent systemThus, it is important that wind turbines also contribute to system frequency control.paper examines the dynamic contribution of doubly fed induction generator (DFIG)-based wind turbine in systemThe simulations carried out in a two-area interconnected power system demonstrate the contribution of

Keywords： doubly fed induction generator (DFIG) load frequency control inertial control wind energy conversion system

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Load frequency control in deregulated power system with wind integrated system using fuzzy controller

Yajvender Pal VERMA, Ashwani KUMAR

Frontiers in Energy 2013, Volume 7, Issue 2, Pages 245-254 doi: 10.1007/s11708-012-0218-6

Abstract: presents the analysis of load frequency control (LFC) of a deregulated two-area hydro-thermal power systemThe conventional two-area power system is modified to study the effects of the bilateral contracts ofcompanies on the system dynamics.The overall inertia of the system reduces, as the wind unit does not provide inertia and isolates fromThe DFIGs integrated provide inertial support to the system through modified inertial control scheme,

Keywords： frequency regulation fuzzy controller de-regulated power system doubly fed induction generator (DFIG)

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Qian Xuesen and System Engineering

Miao Dongsheng

Strategic Study of CAE 2002, Volume 4, Issue 3, Pages 16-20

Abstract:

This paper have looked back the formation of Qian Xuesen's system engineering idea, given a briefaccount of the main points of the system engineering theory with Chinese characteristics, and analysedhow Qian went beyond system engineering.

Keywords： Qian Xuesen system idea system engineering system science

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China’s hydropower energy system toward carbon neutrality

Frontiers of Engineering Management Pages 677-682 doi: 10.1007/s42524-022-0196-2

Abstract: stochasticity, high volatility, and unadjustable features, have great impacts on the safe operation of power systemThus, an advanced hydropower energy system serving multiple energies is required to respond to volatilityFuture research and application can be considered from three aspects: 1) system expansion (e.g., the

Keywords： hydropower system carbon neutrality artificial intelligence

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Title Author Date Type Operation

Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5

Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li

Journal Article

P50 auditory sensory gating in first onset schizophrenics and normal healthy adults

WANG Hongxing, ZHANG Mingdao, CHEN Xingshi, LOU Feiying, LIANG Jianhua, CHEN Chong, SHI Tiantao, LU Qiulin

Journal Article

Behavioral methods for the functional assessment of hair cells in zebrafish

Qin Yang, Peng Sun, Shi Chen, Hongzhe Li, Fangyi Chen

Journal Article

Past review, current progress, and challenges ahead on the cocktail party problem

Yan-min QIAN, Chao WENG, Xuan-kai CHANG, Shuai WANG, Dong YU

Journal Article

Towards human-like and transhuman perception in AI 2.0: a review

Yong-hong TIAN,Xi-lin CHEN,Hong-kai XIONG,Hong-liang LI,Li-rong DAI,Jing CHEN,Jun-liang XING,Jing CHEN,Xi-hong WU,Wei-min HU,Yu HU,Tie-jun HUANG,Wen GAO

Journal Article

System reliability and system resilience

Journal Article

Engineering, Engineering System, Engineering System Theory, and System of Engineering Science

Wang Liancheng

Journal Article

Cyber–Physical Power System (CPPS): A review on measures and optimization methods of system resilience

Journal Article

Discussion on the System Optimization of the Energy Development Strategy and Plan

Da-di Zhou

Journal Article

Distributed monitoring and diagnosis system for hydraulic system of construction machinery